Dimethyl Sulfoxide
Apexbio Technology LLC Idarubicin HCl 57852-57-0 10mM (in 1mL DMSO)
Idarubicin hydrochloride an anthracycline derivative structurally related to daunorubicin acts primarily by inhibiting DNA topoisomerase II It exerts cytotoxic effects through stabilization of DNA-topoisomerase II intercalation complexes inducing DNA strand breaks and apoptosis Idarubicin can be enzymatically activated intracellularly via NADPH-cytochrome C reductase enhancing DNA damage Experimentally it is commonly utilized in leukemia research particularly acute myeloid leukemia (AML) assessing cellular response to DNA damage apoptosis induction and mechanisms underlying drug resistance Idarubicin exhibits IC50 values typically ranging from low nanomolar to micromolar concentrations depending on cell line and assay conditions
Cayman Chemical L-MethIonIn SulfoxIde 1g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Apexbio Technology LLC ASC-J9(Synonyms: Dimethylcurcumin, GO-Y025, AR degrader enhancer ASC-J9), 10mM (in 1mL DMSO), CAS: 52328-98-0.
ASC-J9 (CAS 52328-98-0) is a small-molecule degrader targeting androgen receptor (AR) By promoting degradation of full-length AR and splice variants such as AR3/fAR ASC-J9 inhibits androgen receptor signaling pathways involved in castration-resistant prostate cancer (CRPC) progression and metastatic behavior ASC-J9 interferes with AR-dependent transcriptional modulation and AR-independent signaling pathways notably inhibiting STAT3 phosphorylation and CCL2 chemokine secretion thus reducing macrophage infiltration and prostate cancer invasiveness Research indicates ASC-J9 may represent an alternative therapeutic strategy for CRPC treatment and metastasis prevention
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide anhydrous, 99.9, 67-68-5, MFCD00002089
Dimethyl sulfoxide anhydrous, 99.9
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 100mL
Linear Formula (CH3)2SO, ≥99.9%, Molecular Weight 78.13, ACS reagent, Synonym: DMSO
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide anhydrous, 99.9, 67-68-5, MFCD00002089
Dimethyl sulfoxide anhydrous, 99.9
Cell Signaling Technology DMSO (Dimethyl Sulfoxide), Sterile 10 ml
DMSO (Dimethyl Sulfoxide), Sterile 10 ml
Apexbio Technology LLC Fluvastatin Sodium 93957-55-2 10mM (in 1mL DMSO)
Fluvastatin Sodium (CAS 93957-55-2) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme in cholesterol biosynthesis By blocking HMG-CoA reductase activity fluvastatin reduces serum total cholesterol LDL-cholesterol and apolipoprotein B while increasing HDL-cholesterol and apolipoprotein A-I levels In research settings fluvastatin exhibits anti-atherosclerotic anti-thrombotic and antioxidant properties Studies have shown fluvastatin decreases platelet aggregation dose-dependently in vitro reducing platelet aggregation by approximately 10-15% at clinical doses (40 mg/day) Additionally fluvastatin inhibits inflammatory angiogenesis and NO production suggesting potential applications in inflammatory and cardiovascular research
Apexbio Technology LLC Evacetrapib (LY2484595) 1186486-62-3 10mM (in 1mL DMSO)
Evacetrapib (LY2484595 CAS 1186486-62-3) is a potent and selective inhibitor targeting cholesteryl ester transfer protein (CETP) a regulator of lipid metabolism Evacetrapib exhibits inhibitory activity with IC50 values of 5 5 nM in assays containing recombinant human CETP and 26 nM within human plasma CETP assays In vivo oral administration at 30 mg/kg in human CETP/ApoAI double-transgenic mice significantly reduces CETP activity and elevates HDL-cholesterol concentration (ED50 5 mg/kg) Evacetrapib does not elevate blood pressure nor induce aldosterone or cortisol synthesis in model systems highlighting its potential in cardiovascular research related to coronary artery disease