Dimethyl Sulfoxide
Apexbio Technology LLC Pyridostatin | 1085412-37-8 | 596.6 g/mol | 10MM IN 1ML DMSO
Pyridostatin | 1085412-37-8 | 596.6 g/mol | 10MM IN 1ML DMSO
Apexbio Technology LLC Mitomycin C 10mM (in 1mL DMSO)
Mitomycin C (CAS 50-07-7) is an antibiotic compound derived from Streptomyces caespitosus or Streptomyces lavendulae exhibiting anti-cancer properties by interfering with DNA synthesis Its mode of action involves direct formation of covalent adducts with DNA impeding DNA replication In PC3 cells mitomycin C presents an EC50 of approximately 0 14 M Moreover it can potentiate apoptosis induced by TRAIL (TNF-related apoptosis-inducing ligand) through mechanisms independent of p53 modulating apoptosis-related protein expression and caspase activation Due to its cytotoxic mechanism mitomycin C continues to serve as a useful compound in cancer research particularly in apoptosis signaling studies
Apexbio Technology LLC Etodolac 41340-25-4 10mM (in 1mL DMSO)
Etodolac (CAS 41340-25-4) is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDs) It exhibits inhibitory activity against COX-2 with an IC50 of 53 5 nM Etodolac is commonly utilized for research involving inflammatory conditions such as osteoarthritis and rheumatoid arthritis In isolated rabbit articular chondrocytes stimulated with TNF Etodolac prevented apoptotic cell shrinkage and suppressed caspase-3/7 activation Conversely in human malignant rhabdoid tumor cells (FRTK-1) Etodolac induced apoptosis in a dose-dependent manner increasing activities of caspase-3 -8 and -9
Apexbio Technology LLC Anacetrapib (MK-0859) 875446-37-0 10mM (in 1mL DMSO)
Anacetrapib (MK-0859 CAS 875446-37-0) is a selective inhibitor of cholesteryl ester transfer protein (CETP) an enzyme involved in mediating the transfer of cholesteryl esters and triglycerides between lipoproteins In biochemical assays anacetrapib exhibits potent inhibition of CETP-driven lipid transfer with reported IC50 values of 16 nM for cholesteryl ester transfer and 29 nM for triglyceride transfer Metabolically it undergoes oxidation via CYP3A4 to form metabolites M1 M2 and M3 Due to its effect of significantly lowering LDL cholesterol and elevating HDL cholesterol anacetrapib is studied in research related to primary hypercholesterolemia and mixed dyslipidemia
Apexbio Technology LLC CUDC-907 1339928-25-4 10mM (in 1mL DMSO)
CUDC-907 (CAS 1339928-25-4) is a dual inhibitor targeting histone deacetylases (HDACs 1 2 3 10) and class I phosphatidylinositol 3-kinases (PI3K) It exhibits nanomolar inhibitory activity against these enzymes blocking PI3K-mediated Akt signaling and increasing acetylation of histones and non-histone substrates (e g tubulin p53) In cancer cell models CUDC-907 induces G2-M phase arrest and reduces phosphorylation of downstream proteins such as p70S6 4EBP-1 MEK STAT3 and SRC Preclinical studies demonstrate its anti-tumor activity in lymphoma and NSCLC xenografts making it relevant for oncology research
Medchemexpress LLC Carbocysteine sulfoxide | 5439-87-2 | MFCD21364079 | 99.0% | 195.19 | C5H9NO5S | 25 MG
Carbocysteine sulfoxide is a small-molecule drug intermediate and a reported impurity of carbocisteine supplied for research and analytical use. It is intended for impurity profiling, method development, and related analytical applications. The compound is identified by CAS number 5439-87-2 and has formula C5H9NO5S and a molecular weight of 195.19 g/mol. Storage and handling recommendations are provided in the product certificate of analysis.
Supply Solutions Dextran sulfate sodium salt from Leuconostoc spp., average mol wt ~40,000
A research chemical with the chemical formula C6H5CH2CH2NH2. It is supplied as a colorless to pale yellow liquid with a molecular weight of 121.18 g/mol. This aromatic amine has a density of 0.964 g/mL at 25C and a boiling point of 184-185C. It can be used as a precursor to make other organic compounds. D2650 is sold in a variety of sizes ranging from 5g to 500g. It should be handled carefully as it is harmful if swallowed, inhaled or absorbed through the skin. Proper PPE like gloves and goggles should be worn.
Medchemexpress LLC HY-Y0320 500mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 500mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-Y0320 200mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 200mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Floxuridine 50-91-9 10mM (in 1mL DMSO)
Floxuridine is an antineoplastic antimetabolite compound functioning through inhibition of thymidylate synthase leading to interference with thymidine nucleotide biosynthesis This interruption induces DNA replication stress characterized by formation of double-strand DNA breaks Floxuridine exposure activates cellular DNA damage response pathways specifically ATR and ATM kinase signaling cascades and leads to the phosphorylation of checkpoint kinase 1 (Chk1) This compound has been widely utilized in oncology research to analyze DNA damage mechanisms cellular proliferation inhibition and apoptosis induction in human tumor cell lines Floxuridine demonstrates antiproliferative activity in cell-based assays with reported IC50 values typically ranging between 50 nM and 500 nM depending on cell line and experimental conditions
Apexbio Technology LLC Golgicide A 1139889-93-2 10mM (in 1mL DMSO)
Golgicide A is a reversible small-molecule inhibitor targeting the guanine nucleotide exchange factor GBF1 GBF1 functions as an ArfGEF facilitating Arf1 activation and COPI recruitment at the cis-Golgi membranes essential for Golgi structure maintenance and protein transport regulation Golgicide A disrupts Golgi morphology leading to dispersion of Golgi markers and altered COPI localization In cellular assays Golgicide A inhibits shiga toxin-mediated protein synthesis with an IC50 of approximately 3 3 M in Vero cells and impairs retrograde toxin trafficking and secretory protein transport Additionally Golgicide A is applied in HCV research to reduce viral RNA replication and alter NS5A localization causing accumulation of viral particles in infected cells
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ReagentPlus(R), >=99.5% | 67-68-5 | MFCD00002089 | 10L
Dimethyl sulfoxide ReagentPlus(R), >=99.5% | Purity: >=99.5% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 10L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ReagentPlus(R), >=99.5% | 67-68-5 | MFCD00002089 | 4L
Dimethyl sulfoxide ReagentPlus(R), >=99.5% | Purity: >=99.5% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 4L