Dimethyl Sulfoxide
Apexbio Technology LLC LY2874455(Synonyms: LY-2874455, LY 2874455, FGFR inhibitor LY2874455, Fibroblast growth factor receptor inhibitor LY2874455), 10mM (in 1mL DMSO), CAS: 1254473-64-7.
LY2874455 (CAS 1254473-64-7) is a small molecule inhibitor targeting fibroblast growth factor receptors (FGFRs) proteins functioning through ligand-induced receptor dimerization and tyrosine kinase activation By blocking FGFR phosphorylation and downstream signaling pathways LY2874455 inhibits proliferation and migration in FGFR-dependent cancer cell models LY2874455 shows inhibition of FGFR phosphorylation in FGFR1- FGFR2- and FGFR3-expressing cancer cell lines and xenografts demonstrating antitumor efficacy across various FGFR-driven tumor types It serves as a valuable tool molecule in oncology research investigating FGFR-mediated cancers
Apexbio Technology LLC PD98059 167869-21-8 10mM (in 1mL DMSO)
PD98059 (CAS 167869-21-8) is a selective reversible inhibitor of MAP kinase kinase (MEK/MAPK/ERK kinase) It specifically targets MEK1 affecting both basal and partially activated forms with a reported IC50 of approximately 10 M Treatment with PD98059 inhibits ERK1/2 phosphorylation in a dose-dependent manner resulting in downregulation of cyclin E/Cdk2 and cyclin D1/Cdk4 complexes In cell-based studies such as human leukemia U937 cell models treatment leads to cell growth arrest at the G1 phase and induction of apoptosis PD98059 is widely employed in research investigating signaling pathways involving ERK activation cell cycle regulation and apoptosis
Apexbio Technology LLC GW5074 220904-83-6 10mM (in 1mL DMSO)
GW5074 (CAS 220904-83-6) is a synthetic small molecule inhibitor targeting c-Raf kinase with an IC50 of approximately 9 nM GW5074 displays selectivity for c-Raf showing little or no inhibitory activity against various other kinases including cdk1 cdk2 c-src p38 MAP kinase VEGFR2 c-fms and JNK In neuronal cells GW5074 decreases phosphorylation at serine 259 of c-Raf resulting in c-Raf activation At concentrations below 1 M GW5074 confers neuroprotection by sustaining Akt phosphorylation preventing GSK3 activation and thus reducing apoptosis In vivo GW5074 mitigates neurodegeneration in a 3-nitropropionic acid-induced Huntington s disease model demonstrating promise for neurodegenerative research applications
Apexbio Technology LLC PTC-209 315704-66-6 10mM (in 1mL DMSO)
PTC-209 (CAS 315704-66-6) is a small-molecule inhibitor targeting BMI-1 identified through Gene Expression Modulation by Small molecules (GEMS) technology It acts by suppressing BMI-1 expression at the transcriptional level displaying an IC50 of approximately 0 5 M In HCT116 cells PTC-209 reduces both UTR-mediated and endogenous BMI-1 expression It selectively restricts cell proliferation in certain tumor and stem cell types including U937 HT1080 and human hematopoietic stem cells without affecting viability in cell lines such as HEK293 and HT1080 Thus PTC-209 is primarily utilized in studies exploring cancer stem cell growth and oncogenesis involving BMI-1 and the PRC1 complex
Apexbio Technology LLC Eptifibatide 188627-80-7 10mM (in 1mL DMSO)
Eptifibatide is a cyclic heptapeptide belonging to the glycoprotein IIb/IIIa inhibitor category functioning as an antagonist of platelet adhesion by reversibly binding to the platelet glycoprotein IIb/IIIa receptor This receptor located on platelet surfaces mediates platelet aggregation through binding fibrinogen and von Willebrand factor processes essential in thrombus formation By blocking the GP IIb/IIIa receptor binding site Eptifibatide inhibits fibrinogen-dependent platelet cross-linking reducing platelet aggregation In biomedical research Eptifibatide serves as a pharmacological tool to investigate platelet function thrombosis mechanisms and related cardiovascular diseases in preclinical and clinical models
Apexbio Technology LLC AZD6482 1173900-33-8 10mM (in 1mL DMSO)
AZD6482 (CAS 1173900-33-8) is a selective ATP-competitive inhibitor of phosphoinositide 3-kinase beta (PI3K ) It exhibits inhibitory potency with IC50 values of 0 69 nM for PI3K compared to 13 6 nM for PI3K 47 8 nM for PI3K and 136 nM for PI3K In vitro AZD6482 reduces insulin-induced glucose uptake in human adipocytes (IC50 of 4 4 M) Preclinical studies in dogs indicate anti-thrombotic activity without elevating bleeding risks Clinical evaluation showed good tolerability in human volunteers with modest effects on insulin sensitivity parameters AZD6482 serves as a valuable tool to investigate PI3K function in platelet biology and metabolic regulation
Apexbio Technology LLC Probenecid 57-66-9 10mM (in 1mL DMSO)
Probenecid is an inhibitor targeting organic anion transporters multidrug resistance-associated proteins (MRPs) and pannexin-1 channels showing an IC50 of 150 M for pannexin-1 inhibition MRPs a class of ATP-binding cassette (ABC) transporters mediate efflux of diverse molecules across cellular membranes contributing to drug resistance Probenecid counteracts MRP-mediated drug resistance in multidrug-resistant tumor cell lines enhancing cellular sensitivity to chemotherapeutic agents like daunorubicin and vincristine In animal research Probenecid protects neurons against ischemia/reperfusion-induced injury suppressing inflammation-associated enzyme activity and reducing glial cell activation
Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 10mM (in 1mL DMSO), CAS: 130370-60-4.
Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
Apexbio Technology LLC Aprepitant 170729-80-3 10mM (in 1mL DMSO)
Aprepitant (MK-0869) is a highly selective antagonist of the neurokinin-1 (NK-1) receptor functioning by competitively inhibiting substance P (SP) an undecapeptide belonging to the tachykinin family from activating NK-1 receptors Its binding affinity for human NK-1 receptors is indicated by a dissociation constant (Kd) of approximately 86 pM In cellular models overexpressing NK-1 receptors including glioma (GAMG) neuroblastoma (SKN-BE2 IC50 19 6 M IMR-32 IC50 27 7 M KELLY IC50 30 4 M) retinoblastoma (Y-79 IC50 23 M WERI-Rb-1 IC50 31 2 M) pancreatic cancer (PA-TU-8902 IC50 27 4 M CAPAN-1 IC50 22 7 M) and colon cancer (SW-403 IC50 30 5 M) aprepitant application has been reported to inhibit tumor cell proliferation in vitro
Apexbio Technology LLC Forskolin 66575-29-9 10mM (in 1mL DMSO)
Forskolin (CAS 66575-29-9) is a diterpenoid isolated from the plant Coleus forskohlii known to directly activate adenylate cyclase type I thereby elevating cellular cyclic AMP (cAMP) concentrations It exhibits an IC50 of approximately 41 nM against adenylate cyclase By increasing intracellular cAMP forskolin modulates signaling pathways involved in inflammation and oxidative stress reducing macrophage activation and subsequent production of thromboxane B2 and superoxide Forskolin has been explored in various experimental models and clinical contexts including cardiovascular disorders diabetes mellitus and asthma research
Apexbio Technology LLC BPTES 314045-39-1 10mM (in 1mL DMSO)
BPTES (CAS 314045-39-1) is a selective inhibitor of kidney-type glutaminase (GLS) an enzyme responsible for converting glutamine to glutamate and ammonia It exhibits inhibitory activity against GLS with a reported Ki of approximately 3 M GLS-mediated glutamine metabolism is particularly essential in proliferating and malignant cells BPTES reduces glutamine-to-glutamate conversion in tumor cells diminishing the transamination of pyruvate to alanine as observed in decreased alanine-to-pyruvate ratios in animal models In vitro BPTES inhibits growth by approximately 50% of IDH1-mutant AML cells at 20 M concentration but does not significantly affect wild-type AML cells highlighting its relevance for cancer metabolism research
Medchemexpress LLC HY-Y0320 500mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 500mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Epoxomicin 134381-21-8 10mM (in 1mL DMSO)
Epoxomicin (CAS 134381-21-8) is a naturally occurring proteasome inhibitor initially isolated from actinomycete cultures It acts primarily by forming covalent bonds through its -epoxyketone moiety with catalytic residues of the proteasome resulting in potent inhibition of the chymotrypsin-like (CTRL) activity of the 20S proteasome subunit Epoxomicin also inhibits proteasomal trypsin-like and peptidyl-glutamyl peptide hydrolysis activities albeit at significantly lower rates It exhibits anti-inflammatory and antitumor activities and is employed experimentally to study ubiquitin-proteasome-mediated cellular pathways bone formation regulation and Parkinson s disease model generation
Medchemexpress LLC Jsh-23 10Mm 1Ml Dmso Solution | HY-13982-10MM 1ML DMSO
Jsh-23 10Mm 1Ml Dmso Solution